Research / Hypotheses
Claims with a visible exit.
A hypothesis belongs here only when it can lose. The registry records the active claim, current evidence boundary, strongest competing explanation and the result that would kill or downgrade it.
HΣ‑RPRIMARY / ACTIVE
NEW PROJECT 150 HYPOTHESISIndependent reference-channel hypothesis
Aged tissue fails when the effective number of independent reference channels falls below the level required to detect and contain common-mode drift.
- Evidence boundary
- No direct causal test. Motivated by human observational network data, spatial atlases, morphostasis prior art, cell competition and systems theory.
- Strongest competitor
- Mean damage, cell composition, single-pathway, somatic selection and morphostasis models.
- Kill criterion
- Matched-burden manipulation changes covariance but not hard function, or a simpler model predicts the data equally well.
- Systems Biology
- Spatial Biology
- Fault Containment
HΣPRIMARY / ACTIVE
NEW PROJECT 150 HYPOTHESISSpatiotemporal error-covariance hypothesis
At matched mean burden, common error modes and propagation radius independently reduce functional reserve.
- Evidence boundary
- Untested as a general aging principle. Direct human evidence: none.
- Strongest competitor
- Covariance is a downstream footprint of damage, composition or shared exposure.
- Kill criterion
- Fault geometry has no reproducible effect across two orthogonal fault classes.
- Aging
- Systems Biology
- Spatial Biology
H‑REFCONDITIONAL CANDIDATE
NEW PROJECT 150 HYPOTHESISDistributed adult reference microdomains
Small, correctly positioned adult tissue microdomains may provide local positional, mechanical and immune reference information to untreated neighbours.
- Evidence boundary
- Strong prior art in niches, positional information, organisers and mosaic effects; no human aging intervention evidence.
- Strongest competitor
- Any effect is explained by local secretome dose or generic trophic support.
- Kill criterion
- Correct location provides no additional neighbour correction after cell count and secretome are matched.
- Regeneration
- Spatial Biology
- Cancer Safety
H‑ACTMEASUREMENT CANDIDATE
NEW PROJECT 150 HYPOTHESISActive controllability tomography
Small, reversible, orthogonal perturbations may identify the local response kernel, delays and safe directions of an aged biological system better than passive biomarkers.
- Evidence boundary
- Motivated by perturbation biology, system identification and recovery research; not validated as an aging controller.
- Strongest competitor
- Baseline function and standard measures predict benefit and harm just as well.
- Kill criterion
- Dynamic probes fail external validation or do not outperform standard assessment.
- AI Research
- Systems Biology
- Longevity